Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Bruce Gutman Bruce Gutman

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression

Depression is a significant global health issue, and for those with treatment-resistant depression (TRD), finding an effective treatment can be a daunting challenge. A recent study published in JAMA Network Open sheds light on the benefits of two major treatments for TRD: Ketamine and Electroconvulsive Therapy (ECT). This study provides critical insights that can help patients and healthcare providers make more informed decisions.

Read More
Ketamine Treatment for Depression: Safe for Long-Term Use
Bruce Gutman Bruce Gutman

Ketamine Treatment for Depression: Safe for Long-Term Use

Ketamine, a medication traditionally used as an anesthetic, has gained attention for its rapid-acting antidepressant effects, particularly for those struggling with treatment-resistant depression (TRD). Unlike typical antidepressants that can take weeks to show benefits, ketamine often works within hours. However, the effects of a single dose are usually short-lived, leading doctors to develop multidose treatment plans to extend the benefits.

Read More
Breaking Your Sugar Addiction with Modern Weight Loss Medications
Bruce Gutman Bruce Gutman

Breaking Your Sugar Addiction with Modern Weight Loss Medications

Sugar, particularly in its refined form, is one of the most harmful ingredients in our diet today. High consumption of sugar is linked to a slew of health issues, including obesity, type 2 diabetes, heart disease, and dental decay. It induces rapid spikes in blood glucose and insulin levels, playing a crucial role in metabolic syndrome—a cluster of conditions that heightens the risk of heart disease and other health problems. Additionally, sugar contributes to inflammation and is linked to the aging process and the onset of certain cancers.

Read More
Insights from the Phase 2 Trial of Extended-Release Ketamine Tablets
Bruce Gutman Bruce Gutman

Insights from the Phase 2 Trial of Extended-Release Ketamine Tablets

In a groundbreaking study published in Nature, a recent phase 2 clinical trial has brought new hope for patients suffering from treatment-resistant depression (TRD). The trial tested the efficacy and safety of extended-release ketamine tablets (R-107) and presented promising results that could significantly alter the landscape of depression treatment.

Read More
Ketamine Compared to Traditional Antidepressants
Bruce Gutman Bruce Gutman

Ketamine Compared to Traditional Antidepressants

Depression, a multifaceted mental health disorder, affects millions worldwide. While traditional antidepressants like SSRIs, SNRIs, and Tricyclic/Tetracyclic Antidepressants have been the standard treatment for years, ketamine offers a novel approach that goes beyond symptom management, targeting the root causes of depression.

Read More
Understanding Ketamine's Unique Effects on Synaptic Plasticity and Depression Treatment
Bruce Gutman Bruce Gutman

Understanding Ketamine's Unique Effects on Synaptic Plasticity and Depression Treatment

Ketamine, often known as a rapid-acting antidepressant, has generated significant interest in the field of mental health. This article delves into the recent findings from a study titled "Ketamine induced synaptic plasticity operates independently of long-term potentiation" by Michelle K. Piazza, Ege T. Kavalali, and Lisa M. Monteggia. We'll explore the study's key points in a simplified manner to help you grasp how ketamine affects brain function and its implications for treating depression.

Read More
Ketamine vs. Benzodiazepines and SSRIs for Anxiety 
Bruce Gutman Bruce Gutman

Ketamine vs. Benzodiazepines and SSRIs for Anxiety 

Anxiety disorders are among the most common mental health issues worldwide, affecting millions of individuals and significantly impairing their quality of life. Traditionally, benzodiazepines (benzos) and selective serotonin reuptake inhibitors (SSRIs) have been the primary treatments. However, these medications often come with significant drawbacks, including dependency, withdrawal symptoms, and delayed onset of action.

Read More
Misaligned Incentives in Healthcare
Bruce Gutman Bruce Gutman

Misaligned Incentives in Healthcare

At Well3, we believe in providing access to healthcare tools before it's too late. Individuals should be able to access weight loss medications before becoming overweight, and mental health treatments before enduring years of depression and anxiety. We advocate for proactive healthcare, ensuring you receive the necessary tools to address health issues early, before they escalate.

Read More
Deep Work: Our First Ketamine-Assisted Therapy Program
Bruce Gutman Bruce Gutman

Deep Work: Our First Ketamine-Assisted Therapy Program

We are excited to launch our inaugural ketamine-assisted initiative: DEEP Work. This six-week intensive program is tailored for men committed to deep personal healing, growth, and finding a sense of community. Led by Ted Rider, with over three decades of experience in transformative practices, this program blends teaching, spiritual guidance, and coaching to ensure a secure and conducive environment for significant personal development.

Read More
Healing Chronic Stress Damage to the Brain
Bruce Gutman Bruce Gutman

Healing Chronic Stress Damage to the Brain

Chronic stress is a pervasive issue in today's fast-paced world, affecting millions of people and leading to a myriad of health problems. One of the less visible but profoundly impactful consequences of long-term stress is damage to dendrites, the critical components of neurons responsible for transmitting electrical signals in the brain. This article explores how ketamine, a medication once known primarily for its use in anesthesia, is emerging as a potential tool in repairing dendritic damage caused by chronic stress, offering new hope for recovery and mental health restoration.

Read More
What Motivates Me?
Bruce Gutman Bruce Gutman

What Motivates Me?

In seeking healing, I ventured into the realms of ketamine therapy and psychedelic experiences, with a life-altering ayahuasca retreat in Peru addressing deep-seated trauma from my birth. These journeys taught me to energetically release trauma, offer forgiveness, and, when possible, make personal amends.

Read More
Navigating Hormonal Changes in Aging Women
Bruce Gutman Bruce Gutman

Navigating Hormonal Changes in Aging Women

As women age, they often experience symptoms of hormonal imbalances, particularly related to declining estrogen and progesterone levels, commonly associated with menopause. This natural shift can lead to physical changes such as decreased bone density, potentially resulting in osteoporosis, and alterations in body composition with increased fat deposition.

Well3 provides tools to make it easier to make changes in your life.

Read More
Navigating Low Testosterone for Aging Men
Bruce Gutman Bruce Gutman

Navigating Low Testosterone for Aging Men

As men age, experiencing symptoms of low testosterone, often referred to as "Low T," becomes a typical aspect of the aging process. This natural decline can lead to physical changes such as decreased muscle mass and strength, increased body fat, and reduced bone density, potentially resulting in osteoporosis.

Well3 provides tools to make it easier to make changes in your life.

Read More
Medications Help Change Eating and Lifestyle Habits
Casey Bombacie Casey Bombacie

Medications Help Change Eating and Lifestyle Habits

Habits and behaviors form neural pathways in the brain. Changing a behavior means creating new pathways and weakening old ones, a process that can be time-consuming and difficult.

Well3 provides tools to make it easier to make changes in your life.

Read More
Changing Behaviors is Hard
Casey Bombacie Casey Bombacie

Changing Behaviors is Hard

Habits and behaviors form neural pathways in the brain. Changing a behavior means creating new pathways and weakening old ones, a process that can be time-consuming and difficult.

Well3 provides tools to make it easier to make changes in your life.

Read More
What you believe matters
Bruce Gutman Bruce Gutman

What you believe matters

The beliefs you hold form the foundation of your perception of the world, influencing your thoughts, emotions, and actions. This, in turn, significantly impacts the quality of your life.

Read More