“Just keep swimming,” Dory—the lovable fish from Finding Nemo—famously said. It’s a mantra of persistence and optimism, encouraging us to keep moving forward despite challenges. But what happens when even Dory might feel like giving up? A recent study in Neuron reveals how the brain responds to failure and how ketamine, a surprising player, can help reignite the will to persevere.

This study investigates how ketamine, a drug known for its rapid and long-lasting antidepressant effects, helps repair brain connections in a mouse model of chronic stress. Researchers focused on specific proteins, called planar cell polarity (PCP) proteins, which play a vital role in maintaining healthy communication between brain cells.

In the face of a growing mental health crisis, innovative treatments like ketamine are providing new hope for millions suffering from severe psychiatric conditions. As discussed in a recent episode of Brave New World, the Evening Standard podcast hosted by Evgeny Lebedev, groundbreaking research and therapies are reshaping how we address one of the most pressing challenges of our time.

In a recent episode of Brave New World, the Evening Standard podcast that delves into the future of science, medicine, and humanity, host Evgeny Lebedev spoke with Dr. John Krystal, a leading expert in psychiatry and neuroscience. This compelling discussion shed light on how ketamine is revolutionizing mental health treatment and transforming the understanding of depression.

Is it even possible to avoid burnout in today’s fast-paced world? We live in an age where the lines between work and personal life blur beyond recognition. Emails at midnight. Meetings that stretch into weekends. The digital tether that promises productivity but delivers exhaustion. It’s no wonder burnout has become a silent epidemic, infiltrating every corner of our lives.

In recent years, ketamine has emerged as a groundbreaking therapy for individuals seeking relief from chronic stress, anxiety, depression, and other life challenges. Long known as an anesthetic, ketamine is now being embraced as a powerful tool for mental health and self-improvement, with its transformative potential gaining attention from medical professionals, celebrities, and high achievers in Silicon Valley and beyond.

In today's fast-paced world, mental health is finally getting the attention it deserves. Yet, for many, finding the right treatment can feel like navigating a labyrinth. But what if I told you there are innovative therapies out there that could change your life? Yes, you heard me right! But don't just take my word for it; let's explore these treatment options together and discover how they might just be the key to unlocking better mental health.

For years, scientists have been intrigued by ketamine's seemingly magical ability to alleviate depression almost instantly. While traditionally used as an anesthetic, low doses of ketamine offer a rapid and lasting effect against depression—sometimes in a matter of hours. Recent research from the University at Buffalo has finally uncovered the science behind this phenomenon, providing hope for millions suffering from mental health challenges.

Researchers are discovering how ketamine—a drug traditionally used for anesthesia—has gained a surprising role as a rapid and effective antidepressant. At low doses, a single administration of ketamine can lift depressive symptoms within hours, providing relief that lasts for days, even in cases where conventional antidepressants have failed. But how exactly does ketamine achieve these profound effects? A recent study offers new insights, focusing on how ketamine helps restore damaged brain cell connections, specifically in regions affected by chronic stress and depression.

Over the past few decades, ketamine has emerged as a groundbreaking treatment for depression, especially for those who haven’t found relief with traditional methods. Originally an anesthetic, ketamine’s unique brain effects make it one of the few drugs able to rapidly reduce symptoms of depression in hours. A recent study sheds new light on how ketamine achieves this, targeting specific areas of the brain in a way that could lead to more precise and effective depression treatments.

For people with major depressive disorder (MDD), especially those with recurrent episodes, managing symptoms can be a constant struggle. Suicidal thoughts, a dangerous and common symptom, affect about two-thirds of those with MDD. Traditional antidepressants can take weeks or even months to show effects, and for some, they don’t work at all. But recently, ketamine has emerged as a potential game-changer.

Well3 is introducing a flat rate ketamine therapy program, designed to make treatment more straightforward and affordable for patients. By offering clear pricing based on the type and amount of ketamine administered, the new program ensures that individuals seeking mental health support through ketamine can better plan for their treatment costs.

Well3 is proud to unveil a new flat rate weight loss program, offering simplified pricing based on the amount of medicine required. This initiative is designed to make weight loss treatments more affordable and accessible, especially for individuals with modest weight loss goals.

In light of ongoing developments surrounding GLP-1 medications like Mounjaro and Zepbound, we want to update you on our approach to maintaining access to tirzepatide. As highlighted in the recently on the challenges of supply and demand, there have been significant disruptions in the availability of these medications. However, we are actively working with compounding pharmacies to ensure that we can meet patient needs and avoid the common hurdles seen in recent months.

Ketamine and psilocybin, two substances often discussed in the context of mental health, are making waves in the treatment of conditions like depression and substance use disorder (SUD). These drugs not only work quickly compared to traditional antidepressants, but they also produce powerful changes in how people perceive the world around them. Researchers are starting to ask: Do these "mind-altering" experiences actually help people get better?

In recent years, ketamine has gained recognition as a promising treatment for mental health conditions like depression, anxiety, and PTSD, particularly for patients who haven’t found relief through traditional antidepressants. But what exactly makes ketamine different, and how does it compare to conventional medications like SSRIs and SNRIs? Here's what you need to know.

When your hormones are off, when you’re carrying excess weight, or when your mind is overwhelmed, it’s hard to even imagine what feeling good looks like. That’s when you need to find your own metaphorical hot tub—a way to experience what feeling good is like, even if just for a moment, to remind you that the effort to get there is worth it.

The growing popularity of medications like Ozempic (semaglutide) and Wegovy (another version of semaglutide) for weight loss has brought attention to their ability to help individuals shed pounds and maintain healthier lifestyles. Recently, another medication, tirzepatide (marketed as Mounjaro for type 2 diabetes), has also shown promise for weight management. However, what is less frequently discussed is how these medications can be seen as tools rather than lifelong solutions.

Alcohol use disorder (AUD) is a significant public health issue, affecting millions of adults worldwide, including in the United States. Despite the widespread nature of this problem, only about 20% of those with alcohol issues receive treatment, and the success rate for long-term sobriety remains low. Approximately 75% of individuals who quit drinking relapse within a year. The consequences of AUD extend beyond the individual, impacting families, communities, and society at large. The financial burden on healthcare systems is substantial, with costs estimated in the billions. In response to this pressing issue, researchers in the United Kingdom are conducting the MORE-KARE study to explore the potential of ketamine-assisted psychological therapy to improve treatment outcomes for individuals with severe alcohol use disorder.

Ketamine, a dissociative anesthetic developed in the 1960s, has gained renewed interest in recent years for its potential in treating mental health conditions such as depression, anxiety, and PTSD. Unlike traditional antidepressants, which can take weeks to show effects, ketamine often provides rapid relief. Here are three stories of individuals who have found success with ketamine treatment.