Ketamine for PTSD: A New Hope for Healing?
Post-Traumatic Stress Disorder (PTSD) can be a relentless battle, leaving people stuck in cycles of fear, anxiety, and distress. While traditional treatments like therapy and antidepressants help some, many individuals continue to struggle. A recent study, called OKTOP, explored an alternative approach—using low-dose oral ketamine to treat PTSD. The results offer a glimpse of hope for those seeking new options.
What Was the Study About?
Researchers from the University of the Sunshine Coast conducted a trial to see if weekly oral ketamine doses could help ease PTSD symptoms. Unlike past research that focused on ketamine infusions (given through an IV), this study tested oral ketamine, a simpler and more accessible form.
Who Participated?
The study involved adults diagnosed with PTSD by doctors, psychiatrists, or psychologists. To ensure safety, people with certain health conditions—like severe heart disease, epilepsy, psychosis, or a history of ketamine misuse—were excluded. Participants were allowed to continue taking other prescribed medications during the trial.
How Did the Treatment Work?
One dose per week for six weeks
Liquid ketamine mixed with fruit juice
Starting dose: 0.5 mg per kg of body weight
Dose increased gradually, up to 3 mg per kg
Supervised for at least 60 minutes after each dose
Participants were advised not to drive or engage in risky activities for 12 hours after treatment.
Measuring the Results
To track progress, researchers used well-known PTSD assessment tools, such as the PTSD Checklist (PCL-5) and Clinician-Administered PTSD Scale (CAPS-5). These tests measured symptom changes before, during, and after treatment. Other mental health indicators, like depression, anxiety, sleep quality, and overall well-being, were also monitored.
Did It Work?
The results were promising:
✅ Many participants experienced a 50% reduction in PTSD symptoms after six weeks.
✅ Some continued to see improvements even four weeks after stopping ketamine.
✅ Depression, anxiety, and stress levels also improved.
✅ Most side effects were mild and temporary.
Is Ketamine the Future of PTSD Treatment?
This study suggests that oral ketamine may be an effective treatment for PTSD, offering relief even for those who haven’t responded to traditional therapies. More research is needed, but the findings provide hope for new, accessible treatment options.
https://www.sciencedirect.com/science/article/pii/S0924977X25000045