Ketamine for Depression

When nothing else works, this just might.

A New Option for Hard-to-Treat Depression

For people living with depression, the hardest part isn’t always the sadness—it’s the stuckness. When therapy, lifestyle changes, and antidepressants don’t help, it can feel like you’ve run out of options.

Ketamine is changing that. This treatment offers a powerful alternative for people with treatment-resistant depression, often providing relief within days—not weeks or months.

How Ketamine Works Differently

Most antidepressants work by increasing serotonin. Ketamine takes a different path: it targets the glutamate system, which is involved in learning, memory, and emotional regulation. Specifically, it blocks NMDA receptors, which helps:

Reboot the brain’s stress response
Create new neural connections
Interrupt repetitive, negative thought patterns

In short, it helps your brain reset—so you can feel like yourself again.

Fast Relief, Real Change

Many clients feel noticeable shifts in mood, motivation, or clarity within one to three sessions. These early effects often include:

Emotional lightness or calm
Less rumination
Increased hope or clarity
Renewed ability to connect with others

Unlike medications that may take 4–6 weeks to even begin working, ketamine often creates momentum early in treatment—and that can make a big difference.

Long-Term Benefits

Ketamine doesn’t just lift the fog temporarily. It also promotes neuroplasticity, which helps the brain:

Recover from the wear-and-tear of long-term depression
Form healthier emotional and cognitive pathways
Respond more effectively to therapy or life changes

This makes it an ideal complement to other mental health work, including talk therapy, mindfulness practices, or behavioral strategies.

Who It's For

Ketamine therapy may be especially helpful for people who:

Have tried multiple antidepressants with little or no improvement
Experience emotional numbness
Struggle with motivation, energy, or decision-making
Feel emotionally flat or disconnected from life

If you're not sure whether it's the right fit, our team can help you decide based on your unique situation.

How It Works at Well3

Your journey with us is structured, safe, and supported from day one:

Virtual Consultation – Meet with a licensed provider to discuss your symptoms, goals, and medical history.
Personalized Plan – If appropriate, we’ll create a custom dosing and session schedule for you.
At-Home Treatment – Your medicine is shipped directly to you, with step-by-step guidance.
Follow-Up Support – We check in to track progress and adjust your plan.

You’re not doing this alone. We're here the whole way.

How Many Sessions?

Most people begin with a series of sessions spaced out every other day or twice a week. This schedule allows time for reflection between treatments while maintaining momentum.

Some clients complete their initial course in 2–3 months
Others benefit from ongoing maintenance
The long-term goal is always tapering as you stabilize and grow

We’ll collaborate with you every step of the way to make sure it fits your goals and lifestyle.

Is It Safe?

Ketamine is safe when prescribed and monitored by trained providers. Common short-term side effects include:

Feeling “floaty” or mildly dissociated
Nausea
Sleepiness after sessions

Kat’s Story

“I didn’t realize how much I was surviving, not living.”

After nearly 20 years of relying on benzodiazepines and opioids—medications like Valium and Dilaudid—Kat found a different kind of freedom through ketamine therapy.

For years, she had been managing severe pain, depression, and anxiety stemming from chronic health issues. The medications dulled the edge, but they also dulled everything else. Over time, Kat felt stuck—trapped in a cycle of managing symptoms without ever feeling whole.

Ketamine treatment changed that.

Within weeks of starting therapy, her symptoms began to ease. The constant heaviness lifted. She began to feel present in her body and in her life again. She found herself doing things she hadn’t in years—laughing more, sleeping better, feeling joy in small moments.

But more than symptom relief, ketamine helped her reconnect with herself.

“Setbacks don’t take me out like they used to,” she said. “I feel resilient. Motivated. I’m not reaching for those old prescriptions anymore.”

Kat’s story is one of healing, not just managing. And it’s proof that even after decades of struggle, change is still possible.